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Certain antibiotics become useless over time because

User Boies Ioan
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Commonly prescribed antibiotics are becoming less effective due to a number of reasons:

-overuse of antibiotics
-failing to complete the fully prescribed course by a doctor
-use of antibiotics in farming
These can lead to the effectiveness of antibiotics being reduced, and the incidence of antibiotic resistance increasing. These bacteria are commonly known as superbugs.
User Adz
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