Question

A well-known cell-survival pathway involves a kinase called _______ that is activated by the _______, leading to a larger chance that the cell will survive a stimulus that would normally lead to its destruction

Answer 1

Protein kinase B (PKB); 3,4,5-triphosphorylated phosphoinositide (PIP3)

Explanation:

Protein kinase B (PKB) is a kinase protein involved in receptor tyrosine kinase regulatory pathways. This enzyme attaches ATP-phosphate groups to serine/threonine residues in order to alter the activity of target protein substrates. PKB is involved in many cellular processes including transcription, cell proliferation and apoptosis. PKB is activated by the 3,4,5-triphosphorylated phosphoinositide (PIP3) enzyme and then this kinase propagates the signal to Akt (another serine/threonine kinase) by phosphorylation of its catalytic domain. The Akt/PKB signaling pathway is well-known to promote cell survival in response to extracellular signals/stimuli.