Answer:
Correct answer is C. The people of Mecca opposed his teachings.
Step-by-step explanation:
C is correct because people, especially wealth ones opposed his teachings. They believed that Muhammed will undermine their authority and he had to run away. This event is known as Hijra.
A is not correct as there was no famine. Mecca was a trading center.
B is not correct as Mecca was his birthplace.
D is not correct as he was forced to leave Mecca, but managed to gather many followers in Medina.