Final answer:
Dopamine and glutamate are the two key neurotransmitters located in the nigra striatal region of the brain that play a major role in motor control.
Step-by-step explanation:
The two key neurotransmitters located in the nigra striatal region of the brain that play a major role in motor control are dopamine and glutamate.
The substantia nigra and the ventral tegmental area both contain cell bodies that produce dopamine, which is critical for movement. Degeneration of these regions is involved in Parkinson's disease.
In addition to dopamine, glutamate is also involved in the basal ganglia circuitry and is important for motor function and movement control.