Final answer:
A region is an area defined by specific characteristics, while a theme is a recurring idea that transcends specific places and can be found across different stories or historical events.
Step-by-step explanation:
One major difference between a region and a theme when studying history is that a region deals with one specific place, but a theme can apply in many places. A region is a specific area that can be defined by characteristics such as government, language, political situation, or landform. This allows geographers and historians to analyze a particular area based on these features. On the other hand, a theme refers to a recurring idea or concept that can be found throughout different stories, events, or places. Themes connect plot points, conflicts, and characters to a major idea, such as a broad statement about humanity, life, or our universe, and are not restricted to a specific time period or location.