Question

Pedigree D is most likely X-linked dominant. What is/are the genotype(s) of the parent(s) that transmitted the mutant allele(s) to their offspring

Answer 1

Answer and Explanation:

Note: In the attached file you will find the pedigree and the genotypes of each member.

Parentals) XDXd x XdY

• The female is heterozygous for the trait, transmitting the mutant allele

• The male is not affected.

According to the pedigree, they had the following progeny:

• XdXd healthy female

• XdY healthy male

• XDXd affected female (this individual transmitted the mutant allele)

• XDY affected male (this individual transmitted the mutant allele)

-Both healthy individuals mated with another two healthy individuals. Their whole progeny was healthy.

-The affected female (XDXd) mated with a healthy male (XdY), and they produced 100% healthy individuals

-The affected male (XDY) mated with a healthy female (XdXd) and they had three affected females, XDXd.