Question

A DNA sequence might be the promoter that drives expression of a dynein motor gene. You make a mutation that removes the sequence TATATAT from the −25 region of this putative promoter. If the original sequence serves as a promoter, what should happen to transcription of the dynein motor gene in the mutant?Immersive Reader (2 Points) Nothing should happen. Basal levels of transcription remain. Transcription should decrease. Transcription should increase. Not enough information has been provided to make a good prediction.

Answer 1

Transcription should decrease

Step-by-step explanation:

The TATA box is a consensus sequence of DNA characterized by repetitive thymine (T) and adenine (A) base pairs (bp). It is a consensus sequence that was discovered by David Hogness in 1978. The TATA box is localized in promoter gene regions of archaea and eukaryotic genomes. In animals, the TATA box is often found 30 bp upstream of the transcription start site (TSS). The TATA-box plays a major role during transcription, since it is the site where the preinitiation complex is formed during the initiation of this process. In consequence, mutations in the TATA box region will alter the transcriptional activity.