Final answer:
People who did not follow established religion were often persecuted throughout history.
Step-by-step explanation:
People who did not follow established religion were often persecuted. This is historically evident in various periods and regions. For example, in the Roman Empire, Christians were persecuted for their refusal to participate in the imperial cult. During the Great Persecution in the early 4th century, Christians faced widespread and brutal persecution under the orders of Emperor Diocletian. In the Middle Ages, Jewish communities faced expulsion and other restrictions. The Protestant Reformation in the 16th century also led to religious persecution as different groups clashed with the Catholic Church.