Question

in the case of jesse gelsinger, a young man who died during gene therapy, the therapy involved delivery via a viral vector. was this germ-line or somatic therapy?

Answer 1

somatic therapy

Step-by-step explanation:

Gelsinger suffered from ornithine transcarbamylase deficiency, an X-linked genetic disease of the liver, the symptoms of which include an inability to metabolize ammonia – a byproduct of protein breakdown. The disease is usually fatal at birth, but Gelsinger had a milder form of the disease, in which the ornithine transcarbamylase gene is mutated in only part of the patient's cells, a condition known as somatic mosaicism.