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Warfarin can take days to produce an anticoagulant effect yet produces a transient procoagulant state initially. What is the reason for the delay in effectiveness?

User Mburm
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Answer:

Step-by-step explanation:

The given scenario is primarily present in most cases because warfarin inhibits the enzyme responsible for the recycling of Vitamin K. Therefore, it takes days for desired effect of warfarin to be observed due to the rate of clearance of previously produced y-carboxylated clotting factors (these are the factors you usually see in clotting factors and other proteins of the coagulation cascade.)

User Kyle Xie
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