Answer:
( About ) 1.01371e + 16 ways
Explanation:
You have 21 choices for the first student chosen, 20 choices for the next, then 19, then 18. However, this over-counts everything by a factor of 7! (the number of ways in which four objects can be arranged with regard to order).
Thus, take a look at the procedure below;

This is an approximate answer mind you, so I hope that still helps!