Question

What is the effect of type 2 diabetes (T2D) on pentose phosphate pathway (PPP) flux?

A. T2D results in high basal levels of insulin, which leads to an increase PPP flux

B. T2D has no effect on the PPP

C. T2D prevents an increase in PPP flux in response to elevated levels of blood glucose

D. T2D facilitates an increase in PPP flux in response to elevated levels of blood glucose.

Answer 1

Option A is correct

Step-by-step explanation:

Insulin is responsible for regulating the glucose metabolism through PPP. Insulin increases the G6PD-derived NADPH which regulates several oxido-reductase enzymes. In normal condition, several hormones and nutritional inputs affect the PPP. PPP activity is driven by demand NADPH.

HMG-CoA reductase activity is reduced by G6PD deficiency. G6PD overexpression causes impaired insulin signaling and also increases the level of FFA and TG . Due to impaired insulin signals, the PPP flux increases

Hence, option A is correct