Question

Suppose that a strain of bacteria lacks a key biochemical used in purine synthesis. Complete all the statements about purine synthesis in these bacteria.

_____ will accumulate in bacteria that lack glycine. The atoms of glycine form part of both ring structures. The intermediate _____ will build up in the absence of tetrahydrofolate. N10‑Formyltetrahydrofolate donates _____ to the substrate. _____ will accumulate in the absence of glutamine. Glutamine donates _____. The intermediate ____ will accumulate when aspartate is lacking. Aspartate donates ____.

Answer 1

Answer:1. phosphoribosyl amine

2. glycinamide ribonucleotide

3. a formyl group

4. formylglycinamide ribonucleotide

5. an amino group

6. carboxyaminoimidazole ribonucleotide

7. an amino group

Explanation: Completing all the statements about purine synthesis in these bacteria gives

Phosphoribosyl amine ___ will accumulate in bacteria that lack glycine. The atoms of glycine form part of both ring structures. The intermediate _glycinamide ribonucleotide____ will build up in the absence of tetrahydrofolate. N10‑Formyltetrahydrofolate donates _a formyl group ____ to the substrate. __formylglycinamide ribonucleotide ___ will accumulate in the absence of glutamine. Glutamine donates an amino group _____. The intermediate __carboxyaminoimidazole ribonucleotide__ will accumulate when aspartate is lacking. Aspartate donates __ an amino group

__.