Question

Draw the structure(s) of the product(s) of the Claisen condensation reaction between ethyl propanoate and ethyl formate. Draw only the condensation product, including the self-condensation product if applicable, do not draw the structure of the leaving group. Do not consider stereochemistry.

Answer 1

See explanation below

Step-by-step explanation:

A claisen reaction, is often used between two esters (One of them, usually having alpha hydrogens atoms) to form Beta Keto esters. Depending of the reagents, this reaction is taking place with base where one ester acts as nucleophile and the other as electrophile.

Now, we have here ethyl propanoate and ethyl formate. The ethyl propanoate has two alpha hydrogens, while ethyl formate do not have that. So, the base will react with the ethyl propanoate first, and then, it will react as nucleophile with the formate.

Now, the base to be used in this case will have to be a relatively strong base such sodium ethanoate, because if we use a strong base such NaOH, this will cause the saponification of the ester and not the condensation. So, in order to promove the claisen condensation, we need to use a base not too strong.

In the picture attached you have the mechanism and structure of the final product.