Answer:
4. The number of episodes of pain.
Explanation:
A typical experiment, usually has a response and explanatory variable. A response variable is the major problem we seek to resolve in the experiment. The explanatory variable, on the other hand, provides reasons that would explain the response variable.
In the question asked, we are trying to understand if hydroxyurea can reduce the pain suffered by sickle cell sufferers. The experiment is trying to resolve the problem of pain suffered by sickle cell sufferers. Therefore, this is the response variable.
The explanatory variable would be the drug hydroxyurea which would be used to measure and explain the response variable- the number of episodes of pain.