Question

Which of the following mutations could result in a truncated protein? Choose all that apply. Which of the following mutations could result in a truncated protein? Choose all that apply. A one base pair frameshift A two base pair frameshift A nonsense mutation that changes a cysteine to a stop codon A chromosomal-level insertion A missense mutation that changes a phenylalanine to a leucine A chromosomal-level deletion An in-frame removal of three base pairs

Answer 1

A truncated protein refers to a protein that gets shortened due to a mutation, which does not allow the process of translation to take place properly. The formation of a truncated protein can take place due to a frameshift mutation of one or two base pairs. In such kind of mutation, a single or two base pairs get withdrawn from the sequence resulting in the formation of a completely changed triplicate codon sequence, which may result in the generation of a truncated protein comprising a different set of amino acids.

A nonsense mutation can also result in the formation of a truncated protein. A nonsense mutation generally codes for certain kinds of amino acid, however, post mutation can get converted into a stop codon. This transformation can result in the formation of a truncated protein.

Deletion or insertion at the chromosomal level can also result in the formation of a truncated protein. As insertion and deletion of a certain concentration of DNA can probably lead to the formation of a novel codon that can either be a nonsense codon or a stop codon, which may eventually result in the formation of a truncated protein.

Hence, the correct answers are statements 1st, 2nd, 3rd, 4th, and 6th