Question

The gene for the MyoD transcription factor is introduced into cultured fat cells. When the gene is expressed, the fat cells are transformed into muscle cells. What does this result imply about the fat cells and their commitment to the fat-cell fate? a) They are both committed and irreversibly determined. b) They were neither committed nor determined. c) They are committed to this fate, but not irreversibly determined. d) They are determined, but not committed.

Answer 1

Answer: The correct answer to the question is option C

THEY ARE COMMITTED TO THIS FATE,BUT NOT IRREVERSIBLY DETERMINED.

Fat cells are committed to this fate, but not irreversibly determined.

Explanation: MyoD is also known as myoblast determination protein 1, it is a protein found in animals that plays a crucial role in the regulation of muscle differentiation.

MyoD functions as a transcriptional activator thus promoting transcription of muscle-specific target genes and as well playing a role in muscle differentiation.

Together with MYF5, MYOG, co-occupies muscle-specific gene promoter core region during myogenesis,Inducing fibroblasts to differentiate into myoblasts. Interacts with and is therefore inhibited by the twist protein. This interaction probably involves the basic domains of both proteins.The loss of MyoD facilitates adipogenic transdifferentiation of myoblasts while the overexpression of MyoD transdifferentiate brown preadipocytes to myoblasts.

Answer 2

(C) They are committed to this fate, but not irreversibly determined

Step-by-step explanation:

MyoD is a transcription factor and can also guide the remodelling of chromatin by binding to a DNA motif. Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA.

When fat cells is centrifuged, mature fat cells, or cultured fat cells, are obtained at the uppermost layer.

Fat cells are committed to the fat-cell fate but not irreversibly determined.