The slope is negative. Intuitively, you can see that as x increases (i.e. we move to the right), y decreases (i.e. we move downwards). Using formulas, you can see that the two highlighted points are (4,6) and (8,3). The formula for the slope is

So, in particular, you can see that we have

As for the second questions, the writings

are perfectly equivalent. In fact, 3/4 will always be 0.75, and the rules for the sign tells you that:
positive/negative=negative
negative/positive=negative
-(positive/positive)=-(positive)=negative