Question

Glucagon is a hormone that signals the liver when blood sugar is low. For each of the following enzymes, indicate whether you would expect that glucagon would lead to (A) an increase, (B) a decrease or (C) have no effect on these enzymes activity in the liver.

a. Fructose- 1 ,6-bisphosphatase
b. Fructose-2,6-bisphosphatase
c.Phosphofructokinase- 1
d. Phosphofructokinase-2
e. Phosphorylase kinase
f. Glycogen phosphorylase
g. Glycogen synthase
h. Glyceraldehyde 3-phosphate dehydrogenase
i. Enolase
j. Phosphoglycerate kinase
k. Pyruvate kinase
l. Protein Phosphatase 1A

Answer 1

a. Fructose- 1 ,6-bisphosphatase (High)

b. Fructose-2,6-bisphosphatase (High)

c. Phosphofructokinase- 1 (High)

d. Phosphofructokinase-2 (High)

e. Phosphorylase kinase (Neutral)

f. Glycogen phosphorylase (Low)

g. Glycogen synthase (Low)

h. Glyceraldehyde 3-phosphate dehydrogenase (High)

i. Enolase (High)

j. Phosphoglycerate kinase (High)

k. Pyruvate kinase (High)

l. Protein Phosphatase 1A (Neutral)