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Translate the sequence of amino acids in sickle-cell hemoglobin into (use third valine)
a) mRNA base codes

b) tRNA base codes

c) DNA base codes

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Answer:

Sickle cell hemoglobin occurs in the beta chain of hemoglobin due to point mutation in the sixth codon which changes from glutamic acid to valine which is hydrophobic that causes the change in the size of the RBC in a crescent shape.

The protein or amino acid chain of this condition is as follows:

Protein with Sickle Mutation: VAL HIS LEU THR PRO VAL GLU

which is translated from mRNA sequence

mRNA with Sickle Mutation: G U G C A C C U G A C U C C U G U G G A G

mRNA sequence is the complementary sequence or anticodons of the mRNA sequence RNA:

tRNA with Sickle Mutation: C A C G U G G A C U G A G G A C A C C U C

mRNA sequence is transcribed from the transcription strand of DNA sequence:

DNA with Sickle Mutation: C A C G T G G A C T G A G G A C A C C T C

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