Answer: C. New outbreaks of the Black Death
Step-by-step explanation:
The very infamous Black Death that is said to have killed around 50% of Europe's population, was spread from Asia when the ships that had gone to trade there came back with the infected rats that carried the disease and as the ships went to different cities to trade, they unknowingly spread the disease more.
This would not be the last time diseases were spread from Asia but it was most probably the most devastating case.