Final answer:
Erwin Chargaff's discoveries about the composition of DNA nucleotides led to Chargaff's rules, which state that in any double-stranded DNA, the concentration of adenine equals the concentration of thymine, and the concentration of guanine equals the concentration of cytosine.
Step-by-step explanation:
Erwin Chargaff's discoveries in the 1950s about the composition of DNA nucleotides led to the development of Chargaff's rules. Chargaff found that in DNA, the concentration of adenine (A) is always about the same as the concentration of thymine (T), and the concentration of guanine (G) is always about the same as the concentration of cytosine (C). This is known as Chargaff's rules, which states that in any double-stranded DNA, A equals T and G equals C. These rules were crucial in understanding the structure of DNA and were utilized by Watson and Crick in proposing the DNA double helix model.