Question

As we learned plasma proteins Fibrinogen and Prothrombin are both needed for coagulation. However, there is much more fibrinogen (4% of plasma proteins) compared to prothrombin (present in only small traces). Applying your knowledge of enzymes and clotting cascade, explain the difference in their abundance.

Answer 1

Fibrinogen is present in much higher amounts than what is required for coagulation while Prothrombin is present in low amounts in order to prevent excess conversion to thrombin during blood clotting

Step-by-step explanation:

Fibrinogen is functional for processes such as inflammation, atherogenesis and not for blood Coagulation and they are required to form Fibrin fibers which will in turn form blood clots. Fibrinogen is present in much higher amounts than what is required for coagulation while

Prothrombin is present in low amounts in order to prevent excess conversion to thrombin during blood clotting. and this is because increased concentrations of thrombin will lead to an extensive intravascular thrombosis