This is a combination problem where the order doesn't matter.
We compute the number of combinations with the following formula:
Where n is the number of things to choose from, and we choose r of them. No repetition, the order doesn't matter.
In our problem, we have n = 20 and for r we can pick r = 16 or r =4 (with both options we get the same result), picking r = 16 we get:
Answer
We have 4845 ways possible to get 4 problems correct and 16 problems wrong from a 20 problem set.