The question requires us to calculate the difference between the numbers 9.543 x 10^-5 and 2.544 x 10^-2.
We can calculate the difference between these numbers by a simple subtraction operation. Note that the first number (9.543 x 10^-5) is more than 100 times smaller than the second number, thus our result must be negative. Also, there are four significant figures in both numbers.
Therefore the result is -2.534 x 10^-2 (or -0.02534), considering the four significant figures.