WNV genome is composed of an 11 kb positive RNA fragment that is translated to form a polyprotein. This polyprotein consists of three structural (C, prM/M and E) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) [25]. Phylogenetically, WNV belongs to two major lineages, Lineage 1 and 2.28 Nov 2014