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Which R group would most likely be found in a hydrophobic area of the tertiary structure of a globular protein?

User Kwabena Berko
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1 Answer

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10 votes

Answer:

CH2-Aromatic ring

Step-by-step explanation:

Amino acids with aromatic R groups are relatively hydrophobic and therefore don't interact with water molecules surrounding the protein. Tryptophan (Trp), phenylalanine (Phe) and tyrosine (Tyr) are amino acids with aromatic R groups. Since these amino acids are relatively nonpolar or hydrophobic, they participate in hydrophobic interactions that are strong when there are several residues with aromatic R groups which are stacked on one another. In this regard, it is also important to highlight that Tyr and Trp are more polar than Phe due to the hydroxyl (OH-) group in Tyr and the nitrogen in the Trp ring.

User TavoGLC
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