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If the DNA encoding a nuclear signal sequence were placed in the gene for a cytoplasmic protein, the protein would

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be transported into the nucleus.

The DNA encoding a nuclear signal sequence would tell the protein to be transported into the nucleus, and the protein would then be transported to the nucleus of the cell. The signal sequence acts as a tag that tells the cell where to send the protein within the cell. Once the protein is in the nucleus, it can interact with the DNA and control gene expression.
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