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What appears to be a dark side to telomerase activity with regard to human health?

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While telomerase activity is important for maintaining telomere length and cellular health, there is evidence to suggest that overactivity of telomerase may contribute to certain health issues.

One potential issue is the promotion of cancer cell growth. Telomerase activity is often upregulated in cancer cells, allowing them to maintain their telomere length and continue to divide and grow uncontrollably. Therefore, the use of telomerase inhibitors has been explored as a potential treatment for cancer.

Another potential issue is the association between high telomerase activity and certain age-related diseases, such as cardiovascular disease and neurodegenerative diseases. While the exact mechanisms are not yet clear, it is thought that excessive telomerase activity may contribute to chronic inflammation and oxidative stress, leading to tissue damage and disease progression.

Overall, while telomerase activity is important for maintaining cellular health, it is important to balance this activity to avoid potential negative consequences.

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