Final answer:
Newton's laws best apply at the macrocosmic level, where objects move much slower than the speed of light and are larger than molecules, defining the realm of classical mechanics.
Step-by-step explanation:
The laws described by Newton as outlined in the Principia are found to apply best and produce a good approximation to motion at the macrocosmic level. This includes motion involving objects moving at speeds significantly less than that of light—generally less than about 1% of the speed of light—and when dealing with objects large enough to be seen with a microscope but larger than the size of most molecules (about 10-9 m in diameter). These constraints define the realm of classical mechanics. With the advent of the twentieth century, modern physics, including the theory of relativity developed by Albert Einstein, and quantum theory, emerged to address phenomena where classical mechanics no longer provided an accurate description, such as at very high speeds comparable to the speed of light or at the microscopic scale involving atoms and subatomic particles.