Answer: (x + 3) (x - 3) (x^2 + 9) (x^2 - 9)
Step-by-step explanation: We can use the difference of squares formula to factor x^4 - 81 as (x^2 + 9)(x^2 - 9).
Then, we can use the difference of squares formula again to factor x^2 - 9 as (x + 3)(x - 3).
Therefore, the complete factorization of x^4 - 81 is (x + 3)(x - 3)(x^2 + 9)(x^2 - 9).