Answer: Group 1 and 2 cations are the most reactive on the periodic table. Reactivity increases as you go left across a period, and down a group.
Explanation: Reactivity increases as you go left across a period, and down a group. This is why we hardly see elements like Na in the wild; they bond to become more stable. It's also why the noble gases only bond in rare cases. They have complete octets and are stable the way that they are. Hope this helps.