It is difficult to say exactly how John Locke would respond to human rights issues in the present day, as he lived in the 17th century and did not have the benefit of the knowledge and experiences that we have today. However, based on his philosophy and writings, it is likely that Locke would advocate for the protection and promotion of individual rights and freedoms.
Locke is considered one of the key philosophers of the Enlightenment and is known for his ideas about natural rights and the social contract. According to Locke, every person has certain inalienable rights, including the right to life, liberty, and property, which are protected by a social contract between the individual and the government. Locke believed that the role of government is to protect these rights and that individuals have the right to revolt if the government fails to do so.
Given this, it is likely that Locke would advocate for the protection of human rights in the present day, including the right to life, freedom of expression, and equal treatment under the law. He might also argue that governments have a responsibility to address issues such as discrimination, injustice, and inequality in order to ensure that all individuals have the opportunity to enjoy their rights and live fulfilling lives.