Question

"In which randomized trial design are patients assigned to 2 or more treatment groups where the details of who among the patients get the active drug or the placebo, are only known to the trial sponsor, but not to the clinical investigator nor the patients?"

-Parallel open label design
-Randomized double-blind design
-Randomized blinded design
-Blinded single group design
-Single group design

Answer 1

The randomized trial design where only the trial sponsor knows who receives the active drug or placebo, with clinical investigators and patients remaining uninformed, is known as a Randomized double-blind design.

Step-by-step explanation:

In the context of randomized clinical trials, the design where patients are assigned to two or more treatment groups and the details of who receives the active drug or the placebo are known only to the trial sponsor, but not to the clinical investigator nor the patients, is called a Randomized double-blind design.

This methodology is key to maintaining objectivity in the study, preventing biases from the placebo effect, expectations, or beliefs of both researchers and participants. It also helps in ensuring that the only difference between treatment groups is the treatment imposed by the researcher, thereby isolating the effects of the explanatory variable being tested.