Question

The genes whose specific mutations are known to cause Alzheimer's disease are:

A. Parkin, PINK-1, and UCH-1.
B. APP, PINK-1, and DJ-1.
C. Tau, PHF, and microtuble.
D. APP, PS1, and huntingtin.
E. PS1, PS2 and APP.

Answer 1

Alzheimer's disease is caused by specific mutations in the genes APP, PS1, and PS2, which are linked to early onset Alzheimer's and the formation of beta-amyloid plaques.

Step-by-step explanation:

The specific mutations known to cause Alzheimer's disease are found in the genes: APP (amyloid precursor protein), PS1 (presenilin 1), and PS2 (presenilin 2). These genes are associated with the rare form of early onset Alzheimer's which begins between the ages of 30 and 60. In Alzheimer's disease, mutations in these genes lead to the production of abnormal proteins that are involved in the formation of beta-amyloid plaques, a hallmark of the disease.