Question

The hematopoietin receptor or CD110 is a factor expressed on hematopoietic stem cells, a subfraction of hematopoietic precursor cells and on cells of the megakaryocytic lineage and platelets. CD110 is also the receptor for thrombopoietin. Megakaryocyte proliferation and differentiation are produced upon binding of thrombopoietin to CD110 and stem cells are protected from apoptosis. CD110 is a member of what receptor family?

Class I
Class II
TNF
Chemokine
Immunoglobulin

Answer 1

CD110 is a receptor for thrombopoietin and belongs to the cytokine receptor superfamily, aligning most closely with Class I cytokine receptors.

Step-by-step explanation:

The receptor mentioned, CD110, is the receptor for thrombopoietin, which is a hormone primarily produced by the liver and kidneys. This hormone plays a crucial role in the proliferation and differentiation from megakaryocytes into platelets, also known as thrombocytes.

When thrombopoietin binds to CD110, it not only stimulates megakaryocyte maturation to produce platelets necessary for blood clotting but also contributes to preventing apoptosis in hematopoietic stem cells.

Given the nature of CD110 as a receptor for a hematopoietic growth factor that influences the development of platelets and the survival of stem cells, CD110 is part of the cytokine receptor superfamily, which is not explicitly listed in the options provided.

However, it most closely aligns with Class I cytokine receptors due to its structural features and the signaling pathways it engages.