Question

Early induced immune responses to pathogens are part of innate immunity. One important function of the innate immune response is to recruit more phagocytic cells and effector molecules to the site of an infection. This is accomplished through the release of a battery of cytokines and other inflammatory mediators that have profound effects on subsequent events. The cytokines secreted by phagocytes in response to infection are a structurally diverse group of molecules. What do they include?

MIP-3α
MBL
TNF-α
DUFFY
KELL

Answer 1

The innate immune response utilizes cytokines such as TNF-α and chemokines like MIP-3α to recruit phagocytic cells to the site of infection and mediate inflammation.

Step-by-step explanation:

The innate immune response is critical in the early control of infections. One important function is the recruitment of phagocytic cells to the site of infection. This process involves the release of cytokines and chemokines, which are signaling molecules that regulate immune responses. Cytokines secreted by phagocytes in response to pathogens include a variety of structurally diverse molecules.

Some of the cytokines released are tumor necrosis factor-alpha (TNF-α), interleukins, and chemokines like macrophage inflammatory protein-3 alpha (MIP-3α) and monocyte chemoattractant protein-1 (MCP-1). These substances play pivotal roles in mediating inflammation and directing the cellular defenses of the innate immune system.