Question

VLA-4 antagonists are a new class of compounds that has shown promise in animal models of asthma. This is based on the understanding that VLA-4 acts as a homing receptor for vascular endothelium in sites of inflammation and ensures that activated T cells recirculate through peripheral tissues where they may encounter sites of infection. All of the VLA molecules are members of what family of glycoproteins?

Selectins
Integrins
Streptolysins
Immunophilins
Interleukins

Answer 1

VLA-4 antagonists target the integrin family of glycoproteins. Integrins facilitate cell adhesion and migration, which are crucial in the immune response and inflammation.The correct option is B.

Step-by-step explanation:

VLA-4 antagonists are a type of therapeutic compound investigated for their benefits in treating conditions such as asthma by targeting a specific molecule involved in inflammation. All of the VLA molecules, including VLA-4, are members of the integrin family of glycoproteins.

Integrins are prominent for their role in cell adhesion, mediating the attachment and migration of cells, particularly leukocytes, to sites of inflammation.

This is essential in immune responses, where activated T cells rely on integrins and other molecules like selectins to navigate to and infiltrate tissues at infection sites.The correct option is B.