Question

SDF-1 is a small chemokine of the CXC subfamily that is produced constitutively by bone marrow stromal cells and has an important role in early stages of B cell development. It is a growth factor for B cell progenitors and a chemotactic factor for T cells, monocytes, CD34+ hematopoietic progenitor cells, mature megakaryocytes, and dendritic cells. What is the chemotactic effect of SDF-1 mediated by?

Mac-1
SDF-1
CXCR-4
IL-8
IP-10

Answer 1

The chemotactic effect of SDF-1 is mediated by the CXCR-4 receptor, which helps direct the movement of various cells to the areas where they are required.

Step-by-step explanation:

The chemotactic effect of SDF-1 is mediated by the receptor CXCR-4. SDF-1, or stromal cell-derived factor 1, is a chemokine that is pivotal in hematopoiesis and immune responses. It interacts with CXCR-4 to induce chemotaxis, which is the movement of cells in response to chemical stimuli.

This process is essential for guiding cells to sites where they are needed, such as guiding hematopoietic progenitor cells towards the bone marrow and immune cells towards sites of injury or infection.