Question

Many human autoimmune diseases show HLA-linked disease associations and these have been defined more exactly as HLA genotyping has become more precise through polymerase chain reaction analysis of HLA allele sequences. The association of MHC genotype with autoimmune disease is not surprising, because autoimmune responses involve T cells, and the ability of T cells to respond to a particular antigen depends on MHC genotype. What is one of the most dramatic examples of all HLA-associated diseases?

Autoimmune hemolytic anemia
Wegener's granulomatosis
Chediak-Higashi syndrome
Ankylosing spondylitis
Autoimmune thrombocytopenic purpura

Answer 1

Ankylosing spondylitis is one of the most dramatic examples of a disease associated with HLA genotypes, particularly with the HLA-B27 allele, leading to inflammation and possible fusion of vertebrae.

Step-by-step explanation:

The association between HLA genotypes and certain autoimmune diseases is a result of how the major histocompatibility complex (MHC) proteins, coded by these HLA genes, present self-antigens to T cells, leading to autoimmune responses.

One of the most dramatic examples of HLA-associated diseases is Ankylosing spondylitis. Ankylosing spondylitis is an inflammatory disease that can cause some of the vertebrae in your spine to fuse together, leading to stiffness and chronic pain. The disease has a strong association with the HLA-B27 allele, making HLA genotyping a useful tool in understanding and diagnosing this condition.