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This interaction is necessary with the T cell co-stimulatory molecule

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Final answer:

The interaction necessary with the T cell co-stimulatory molecule is the binding between an antigen-displaying MHC molecule and a complementary T-cell receptor.

Step-by-step explanation:

The interaction that is necessary with the T cell co-stimulatory molecule is the binding between an antigen-displaying MHC molecule and a complementary T-cell receptor (TCR). This interaction is important in the activation of T cells to recognize and destroy invading pathogens.

When a CD4+ helper T cell binds the MHC II-antigen complex on an antigen-presenting cell, both the antigen-presenting cell and the T cell release cytokines, which further contribute to the activation of the immune response.

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