Final answer:
Vatican City is the landlocked enclave in Rome that is the world's smallest country, with approximately 110 acres of territory. It is significantly smaller than other tiny nations such as Tuvalu and Nauru.
Step-by-step explanation:
The landlocked enclave in Rome that is the world's smallest country is Vatican City. It is an independent city-state enclaved within Rome, Italy. With its roughly 44 hectares (110 acres) of territory, this sovereign state is the spiritual and administrative center of the Roman Catholic Church, led by the Pope.
It's also home to iconic art and architecture such as St. Peter's Basilica and the Sistine Chapel. Vatican City is smaller than other very small countries like Monaco and is significantly smaller than island nations like Tuvalu and Nauru, which are among the smallest countries in the world by land area.