Final answer:
Minneapolis is the largest city in Minnesota that lies on the Mississippi River and is known as one of the Twin Cities along with St. Paul.
Step-by-step explanation:
The largest city in Minnesota that, along with St. Paul, is known as the Twin Cities and lies on the Mississippi River is Minneapolis.
Minneapolis is the most populous city in the state and is located on both banks of the river. It is known for its vibrant arts scene, numerous parks, and a thriving economy.
Minneapolis and St. Paul together form the Twin Cities metropolitan area, which is the 16th largest metropolitan area in the United States.