Final answer:
Humans have used mind-altering substances since prehistoric times, with evidence of ritual and recreational use dating back more than 5,700 years and alcohol production at least 9,000 years ago.
Step-by-step explanation:
Humans have used mind-altering substances since prehistoric times, tens of thousands of years ago, well before the 1960s, the Middle Ages, ancient Greece and Rome, or ancient Egypt 4,000 years ago. Evidence of this use includes the rituals involving the mescaline-containing peyote cactus by Native Americans dating back 5,700 years, the use of Amanita muscaria mushrooms in prehistoric Europe, and discoveries suggesting the brewing of alcoholic beverages from rice, barley, and grapes at least 9,000 years ago. Furthermore, wine consumption was a feature of ancient civilizations such as Greece, Egypt, and Rome, where moderation was encouraged except during specific religious festivals.
The earliest instances of chemistry practices that led to substance use can be traced back to the control of fire by humans, which enabled them to cook, make pottery, smelt metals, and later to isolate a variety of drugs from plants, produce alcohol by fermentation, and extract alkalies for the production of soaps.
Thus, the correct answer to the question of when humans began using mind-altering substances is e) during prehistoric times tens of thousands of years ago.