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Which of the following are tumor suppressor genes associated with the development of breast cancer? Select all that apply.

1. BRCA1
2. BRCA2
3. TP53
4. HER2

1 Answer

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Final answer:

The tumor suppressor genes associated with the development of breast cancer include BRCA1, BRCA2, and TP53, whereas HER2 is an oncogene related to aggressive breast cancer.

Step-by-step explanation:

The tumor suppressor genes associated with the development of breast cancer include BRCA1, BRCA2, and TP53. These genes are known to code for proteins that suppress cell proliferation and growth. When these genes are mutated, they can lead to the development of breast cancer due to the loss of their tumor-suppressing functions. BRCA1 and BRCA2 mutations are notably associated with hereditary breast and ovarian cancer, while mutations in TP53 are linked to multiple cancer types, including breast cancer. On the other hand, HER2 is not a tumor suppressor gene; rather, it is an oncogene associated with aggressive breast cancer when overexpressed or amplified, which leads to excessive signaling for cell division.

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