Final answer:
Perseus frequently used a reflective shield to defeat his enemies, primarily Medusa. This weapon is significant in his mythology as it demonstrates his resourcefulness and the assistance he received from the gods.
Step-by-step explanation:
Perseus frequently employed a specific weapon, the reflective shield given to him by the goddess Athena, to defeat his enemies, most notably Medusa. This shield allowed Perseus to look at Medusa's reflection instead of directly at her, preventing him from being turned to stone. The significance of this weapon lies in its role in Perseus' mythological story, where it showcases his resourcefulness and the aid he received from the gods.