Final answer:
In patients with end-stage ischemic heart disease, right ventricular systolic function is often reduced due to compromised contractility, leading to lowered stroke volume and ejection fraction with an increased end systolic volume (ESV). The cardiac cycle is influenced by preload, contractility, and afterload, all of which are adversely affected in ischemic conditions.
Step-by-step explanation:
The right ventricular systolic function in patients with end-stage ischemic heart disease is often impaired due to the damage to the myocardial tissue. In end-stage disease, the ability of the right ventricle to generate adequate pressure to eject blood during systole can be significantly reduced, which may decrease the stroke volume and lead to an increase in the end systolic volume (ESV). With the heart's compromised ability to pump effectively, the ejection fraction, which is the proportion of blood ejected with each contraction relative to the end diastolic volume (EDV), may also decrease. The full cardiac cycle, including both systole and diastole, involves a complex interaction between preload (EDV), contractility, and afterload. In ischemic heart disease, contractility may be decreased due to compromised coronary circulation, and the resulting reduced stroke volume contributes to cardiac dysfunction.
The impact of right ventricular systolic dysfunction in end-stage ischemic disease must also consider factors such as contractility, preload, and afterload. These factors influence the stroke volume, hence affecting the overall cardiac performance. Ischemic damage leads to a reduction in contractility, increasing the heart's effort to pump against resistance (afterload), while preload is affected by various physiological adjustments in an attempt to maintain cardiac output.