Final answer:
Gender variant and intersex individuals face discrimination, healthcare disparities, and legal challenges in their daily lives.
Step-by-step explanation:
The significant social issues that gender variant people and intersex people face in their daily lives include discrimination, healthcare disparities, and legal challenges. Gender variant people may face discrimination in various settings, such as education, employment, and public accommodations, due to their gender identity or expression. Intersex people often experience healthcare disparities and may face unnecessary medical interventions at a young age to conform to societal norms. Furthermore, both gender variant and intersex individuals may encounter legal challenges in countries where their rights and protections are limited.