Final answer:
The global areas of greatest TB drug resistance include the Middle East and North Africa, Asia and the Pacific, and Western and Central Europe and North America.
Step-by-step explanation:
The global areas of greatest tuberculosis (TB) drug resistance include the Middle East and North Africa, Asia and the Pacific, and Western and Central Europe and North America. In these regions, the emergence of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) and extensively drug-resistant Mycobacterium tuberculosis (XDR-TB) has become a significant concern. MDR-TB strains are resistant to both rifampin and isoniazid, while XDR-TB strains are resistant to additional drugs used as a second line of treatment.