Final answer:
Quinolone drugs must be dispensed with a medication guide due to the increased risk of tendon rupture, among other side effects.
Step-by-step explanation:
All quinolone drugs must be dispensed with a medication guide because of the increased risk of tendon rupture. Quinolones, including fluoroquinolones like ciprofloxacin and levofloxacin, are antibiotics that treat bacterial infections by blocking the activity of bacterial DNA gyrase, thus inhibiting DNA replication. However, despite their effectiveness against a broad spectrum of bacteria, these drugs carry side effects such as phototoxicity, neurotoxicity, cardiotoxicity, glucose metabolism dysfunction, and notably, an increased risk for tendon rupture, which necessitates them being dispensed with a medication guide to inform patients of potential risks.